Regulation of Tumor Angiogenesis and Choroidal Neovascularization by Endogenous Angioinhibitors
نویسندگان
چکیده
منابع مشابه
Regulation of Tumor Angiogenesis and Choroidal Neovascularization by Endogenous Angioinhibitors.
Angiogenesis is the process of neovascularization from parent blood vessels, which is a prerequisite for many physiological and pathological conditions and is regulated by a balance between endogenous angioinhibitors and angioactivators or angiogenic factors. Imbalance between angioinhibitors and angioactivators is associated with neovascularization capacity during progression of tumor developm...
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The sense of vision has utmost significance and the loss of vision leads to the impairment of active human behavior as evident in pathological disorders that affect vision. Among different pathological visual disorders, Age Related Macular Degeneration (AMD/ARMD) is of serious concern as a leading cause of blindness, observed with aging globally. The clinical manifestation of AMD includes retin...
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MicroRNAs (miRNAs) modulate complex physiological and pathological processes by repressing expression of multiple components of cellular regulatory networks. Here we demonstrate that miRNAs encoded by the miR-23∼27∼24 gene clusters are enriched in endothelial cells and highly vascularized tissues. Inhibition of miR-23 and miR-27 function by locked nucleic acid-modified anti-miRNAs represses ang...
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PURPOSE Age-related macular degeneration (AMD) is the leading cause of blindness in elderly. The detailed mechanism of choroidal neovascularization (CNV) leads to severe vision loss in patients with AMD. This study was undertaken to evaluate the inhibitory effect of homoisoflavanone on CNV. METHODS Antiangiogenic activity of homoisoflavanone was evaluated by in vitro tube formation assay of h...
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ژورنال
عنوان ژورنال: Journal of Cancer Science & Therapy
سال: 2013
ISSN: 1948-5956
DOI: 10.4172/1948-5956.1000235